Carboxymethylcellulose (CMC; E466) is a chemically modified derivative of cellulose formed by its reaction with alkali and chloroacetic acid.

CAS Number: 9004-32-4.

E number: E466

SKU: 15615132 Category:
  • Description
  • Product Specification


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Carboxymethyl cellulose (CMC), is a derivative of cellulose, a water-soluble polymer. CMC is produced through etherification of cellulose and has properties that caused using it in numerous applications. so This cellulose gum in most instances has proved to be useful.


Chemical formula



Molar mass


263.2 g/mol


slightly hygroscopic white or

slightly yellowish or greyish

odorless and tasteless,

granular or fibrous powder



yields a viscous colloidal solution with water. insoluble in ethanol


Not less than 5.0 and not more than 8.5
Chemical structure   STRUCTURE OF CMC

Synthesis of Carboxymethyl cellulose

CMC was prepared in 1918 for the first time and up to now, it is the most important ionic cellulose product. The way of synthesis is by conversion of alkali cellulose swollen in aqueous NaOH and a surplus of an organic liquid (e.g. ethanol or isopropanol) with monochloroacetic acid or its sodium salt which is a beta-(1,4)-D-glucopyranose polymer. It contains carboxymethyl groups that are produced via the reaction of cellulose with chloroacetate and causes substitutions in the C positions of glucose.


Applications of Carboxymethyl cellulose

Commercial usage of C8H16NaO8 rapidly has increased in recent years. This product does not affect the taste of the foods and Many of them have low energy so they used it in diet food.  and also could be used in detergents, emulsified dyes, drilling muds, pharmacy, cosmetics, health care, etc. We explain some of these applications below:



used as a soil suspension polymer to:

  • design to deposit onto cotton and other cellulose fabrics.
  • in the wash solution, creating a negatively charged barrier to soils.




used as a lubricant for dry eyes to do:

  • the temporary relief of burning, irritation, and discomfort due to dryness of the eyes.
  • lubricate and re-wet soft and rigid gas permeable contact lenses.


  • to relieve dryness, irritation, and discomfort that may be associated with lens wear.


  • make ice cream without extremely low temperatures so eliminating the need for conventional churners or salt ice mixes.
  • as an emulsifier in high-quality biscuits, chewing gums, margarine, and peanut butter by dispersing fat uniformly in the dough.
  • in candy preparation ensures smooth dispersion in flavor oils and improves texture and quality.



Safety information

This product may cause visual disturbances and eye discharge. Some other side effects of it, include redness of the eye, burning and discomfort, eyelid swelling, and itching of the eye.

Also, according to the MSDS paper some points mentioned below:

  1. In case of eye contact: rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention.
  2. In case of skin contact: wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Get medical attention.
  3. In case of inhalation: remove from exposure, lie down. Remove to fresh air. If not breathing, give artificial respiration. Get medical attention.
  4. In case of ingestion: clean mouth with water. Get medical attention.






* Ind. Eng. Chem. 1945, 37, 10, 943–947 (





PRODUCT DESCRIPTION: Carboxymethylcellulose (CMC; E466) is a chemically modified derivative of cellulose formed by its reaction with alkali and chloroacetic acid.

Product Name: Carboxymethylcellulose

CAS Number: 9004-32-4

E Number: E466

Product Specification